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Mass Spectrometry Quiz

Mass Spectrometry Quiz

Test your knowledge on mass spectrometry and its history

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  • 1.
    Until 2019, the kilogram unit was defined using an international prototype kept at the International Bureau of Weights and Measures in France. The International Prototype of the Kilogram was made of an alloy of platinum and one other metal. The metal was:

    Your answer:
    Correct answer:

    The International Prototype of the Kilogram was a cylinder with a height and diameter of 39 mm made of an alloy of 90% platinum and 10% iridium.

  • 2.
    Which element has the largest number of stable isotopes?

    Your answer:
    Correct answer:
    Naturally occurring tin is a mixture of its ten stable isotopes and they are found in the percentages as follows: 112Sn (1.0 %), 114Sn (0.7 %), 115Sn (0.3 %), 116Sn (14.5 %), 117Sn (7.7 %), 118Sn (24.2 %), 119Sn (8.6 %), 120Sn (32.6 %), 122Sn (4.6 %), and 124Sn (5.8 %). Molybdenum has six stable isotopes, ytterbium seven.
  • 3.
    Which mass spectrometer was carried by the American spacecraft Viking 1 sent to the planet Mars in 1975?

    Your answer:
    Correct answer:
    Viking 1 carried two mass spectrometers, both equipped with double-focusing analyzers and electron ionization sources. The first spectrometer with a Mattauch-Herzog geometry was designed by Alfred Nier; it was intended to analyze the upper atmosphere of Mars. The second one with a Nier- Johnson geometry was part of the GC/MS apparatus designed by Klaus Biemann. It was used to analyze the regolith and the atmosphere at the landing site.
  • 4.
    List these compounds according to their increasing mass: hydrazine (H4N2), oxygen (O2), methanol (CH4O).

    Your answer:
    Correct answer:

    The monoisotopic masses of these compounds are 31.989829 Da (oxygen), 32.026215 Da (methanol), and 32.037448 Da (hydrazine).

  • 5.
    Joseph John Thomson (1856 - 1940), Nobel laureate in physics, is credited with the invention of the mass spectrometer, the discovery of the electron and isotopes of stable elements. A lesser-known fact is his father's profession. What was it?

    Your answer:
    Correct answer:

    His father, Joseph James Thomson, ran an antiquarian bookshop founded by Thomson’s great-grandfather. [Wikipedia]

  • 6.
    John Zeleny was an American physicist whose work laid the theoretical foundations of electrospray ionization. He was born in 1872 into a family of immigrants from Europe. Where did his family come from?

    Your answer:
    Correct answer:

    The parents of John Zelený, Antonín Zelený and Josefa Pitková, came from Křídla, a small village near Žďár nad Sázavou in Austria-Hungary (now the Czech Republic).

  • 7.
    What was the largest number of quadrupoles connected in series for tandem mass spectrometry in a commercial instrument?

    Your answer:
    Correct answer:
    A penta-quadrupole mass spectrometer contains three quadrupole filters and two rf-only quadrupole collision cells. It allows MS3 experiments.  Extrel once offered such a spectrometer.
  • 8.
    Lunar craters are usually named after scientists and explorers. One of the craters on the Moon is named after a prominent scientist in the field of mass spectrometry. Who is named after?

    Your answer:
    Correct answer:

    Aston is a 44-kilometer lunar impact crater located along the northwestern limb of the Moon. The crater was named in honor of Francis W. Aston.

  • 9.
    What is the trajectory of a charged particle moving perpendicularly to a uniform magnetic field in a vacuum?

    Your answer:
    Correct answer:

    The magnetic force is perpendicular to the velocity so that it does no work on the charged particle. The particle’s kinetic energy and speed thus remain constant. The direction of motion is affected but not the speed.

  • 10.
    The quadrupole mass filter has been known since the mid-1950s thanks to the work of Wolfgang Paul. The motion of ions in a quadrupole field can be described by solving second-order differential equations. When were these equations solved mathematically?

    Your answer:
    Correct answer:

    The solution of differential equations of this type came from the French mathematician Émile Léonard Mathieu (1835-1890), who studied the mechanical vibrations of the elliptical drumheads.

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